Inflammation parameters, monocyte subgroups and toll-like receptor expression before and after dialysis in patients with chronic kidney disease

Abstract Objectives The data of the monocyte subgroups and expressed toll like receptors (TLR) in innate immune system response, which develop against chronic inflammation patients with predialysis kidney disease (CKD) who undergo dialysis treatment, are limited. We aimed to investigate effect procedure on current inflammatory condition role ratios, expressions TLR2/4 serum Tumor necrosis factor alpha (TNF-α) levels involved response process. Methods investigated subgroups, TLR2/TLR4 TNF-α 30 CKD patients, 90 undergoing healthy control subjects. Monocyte subgroup percentages were determined using flow cytometry, enzyme-linked immunosorbent assay (ELISA). Results In classical (p=0.0001) non-classical (p=0.078) monocytes found be higher when compared patients. TLR4 expression was controls (p<0.0001, p=0.796). Serum level significantly (p=0.013, p=0.022) a positive correlation between observed (r=0.285, p=0.006). Conclusions Increased monocytes, might related inflammation.